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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 1
1995 3
1996 2
1997 4
1998 2
1999 3
2000 3
2001 5
2002 6
2003 10
2004 7
2005 3
2006 11
2007 4
2008 8
2009 5
2010 12
2011 19
2012 18
2013 12
2014 18
2015 31
2016 25
2017 21
2018 22
2019 28
2020 18
2021 18
2022 10
2023 21
2024 7

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324 results

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Page 1
Integrated proteogenomic characterization of urothelial carcinoma of the bladder.
Xu N, Yao Z, Shang G, Ye D, Wang H, Zhang H, Qu Y, Xu F, Wang Y, Qin Z, Zhu J, Zhang F, Feng J, Tian S, Liu Y, Zhao J, Hou J, Guo J, Hou Y, Ding C. Xu N, et al. J Hematol Oncol. 2022 Jun 3;15(1):76. doi: 10.1186/s13045-022-01291-7. J Hematol Oncol. 2022. PMID: 35659036 Free PMC article.
RESULT: Proteogenomic integration analysis indicated that SND1 and CDK5 amplifications on chromosome 7q were associated with the activation of STAT3, which was relevant to tumor proliferation. ...
RESULT: Proteogenomic integration analysis indicated that SND1 and CDK5 amplifications on chromosome 7q were associated with the acti …
CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth.
Yin S, Liu L, Ball LE, Wang Y, Bedford MT, Duncan SA, Wang H, Gan W. Yin S, et al. Cell Rep. 2023 Apr 25;42(4):112316. doi: 10.1016/j.celrep.2023.112316. Epub 2023 Mar 29. Cell Rep. 2023. PMID: 36995937 Free PMC article.
Here, we identify protein arginine methyltransferase 1 (PRMT1) as a critical regulator of GATOR2. In response to amino acids, cyclin-dependent kinase 5 (CDK5) phosphorylates PRMT1 at S307 to promote PRMT1 translocation from nucleus to cytoplasm and lysosome, which in turn …
Here, we identify protein arginine methyltransferase 1 (PRMT1) as a critical regulator of GATOR2. In response to amino acids, cyclin-depende …
Biological functions of CDK5 and potential CDK5 targeted clinical treatments.
Shupp A, Casimiro MC, Pestell RG. Shupp A, et al. Oncotarget. 2017 Mar 7;8(10):17373-17382. doi: 10.18632/oncotarget.14538. Oncotarget. 2017. PMID: 28077789 Free PMC article. Review.
While it was previously thought that CDK5 only interacted with p35 or p39 and their cleaved counterparts, Recent evidence suggests that CDK5 can interact with certain cylins, amongst other proteins, which modulate CDK5 activity levels. This review discusses r …
While it was previously thought that CDK5 only interacted with p35 or p39 and their cleaved counterparts, Recent evidence suggests th …
Cdk5 links with DNA damage response and cancer.
Liu W, Li J, Song YS, Li Y, Jia YH, Zhao HD. Liu W, et al. Mol Cancer. 2017 Mar 14;16(1):60. doi: 10.1186/s12943-017-0611-1. Mol Cancer. 2017. PMID: 28288624 Free PMC article. Review.
Recent studies show that Cdk5 participates in a series of biological and pathological processes in non-neuronal cells, and is generally dysregulated in various cancer cells. The inhibition or knockdown of Cdk5 has been proven to play an anti-cancer role through vari …
Recent studies show that Cdk5 participates in a series of biological and pathological processes in non-neuronal cells, and is general …
The ubiquitin E3 ligase FBXO22 degrades PD-L1 and sensitizes cancer cells to DNA damage.
De S, Holvey-Bates EG, Mahen K, Willard B, Stark GR. De S, et al. Proc Natl Acad Sci U S A. 2021 Nov 23;118(47):e2112674118. doi: 10.1073/pnas.2112674118. Proc Natl Acad Sci U S A. 2021. PMID: 34795058 Free PMC article.
We conclude that FBXO22 is a substrate of CDK5, and that inhibiting CDK5 reduces PD-L1 indirectly by increasing FBXO22. Pairing inhibitors of CDK5 with immune checkpoint inhibitors may increase the efficacy of immune checkpoint blockade alone or in combinatio …
We conclude that FBXO22 is a substrate of CDK5, and that inhibiting CDK5 reduces PD-L1 indirectly by increasing FBXO22. Pairin …
A kinase of many talents: non-neuronal functions of CDK5 in development and disease.
Sharma S, Sicinski P. Sharma S, et al. Open Biol. 2020 Jan;10(1):190287. doi: 10.1098/rsob.190287. Epub 2020 Jan 8. Open Biol. 2020. PMID: 31910742 Free PMC article. Review.
Moreover, high levels of CDK5 have been observed in different tumour types, and CDK5 was proposed to play various roles in the tumorigenic process. In this review, we discuss these various CDK5 functions in normal physiology and disease, and highlight the the …
Moreover, high levels of CDK5 have been observed in different tumour types, and CDK5 was proposed to play various roles in the …
CDK5 Knockdown inhibits proliferation and induces apoptosis and Cell Cycle Arrest in Human Glioblastoma.
Zhou Y, Wang X, Lv P, Yu H, Jiang X. Zhou Y, et al. J Cancer. 2021 May 10;12(13):3958-3966. doi: 10.7150/jca.53981. eCollection 2021. J Cancer. 2021. PMID: 34093802 Free PMC article.
Aims: Gliomas are the most common malignant brain neoplasms with high recurrence and lethality rates. Recently, studies have reported that cyclin-dependent kinase 5 (CDK5) is involved in tumorigenesis. ...Results: CDK5 expression was substantially higher in g …
Aims: Gliomas are the most common malignant brain neoplasms with high recurrence and lethality rates. Recently, studies have reported …
CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis.
Wang F, Zhao W, Gao Y, Zhou J, Li H, Zhang G, Guo D, Xie C, Li J, Yin Z, Zhang J. Wang F, et al. J Exp Clin Cancer Res. 2019 Jul 4;38(1):286. doi: 10.1186/s13046-019-1297-6. J Exp Clin Cancer Res. 2019. PMID: 31272499 Free PMC article.
Exogenously expressed CDK5 but not kinase-dead CDK5 promoted proliferation, migration, and invasion of HCC cells. ...More importantly, heterozygous knockout CDK5 (Cdk5+/-) attenuated HCC tumorigenesis induced by diethylnitrosamine. ...
Exogenously expressed CDK5 but not kinase-dead CDK5 promoted proliferation, migration, and invasion of HCC cells. ...More impo …
Development of CDK2 and CDK5 Dual Degrader TMX-2172.
Teng M, Jiang J, He Z, Kwiatkowski NP, Donovan KA, Mills CE, Victor C, Hatcher JM, Fischer ES, Sorger PK, Zhang T, Gray NS. Teng M, et al. Angew Chem Int Ed Engl. 2020 Aug 10;59(33):13865-13870. doi: 10.1002/anie.202004087. Epub 2020 Jun 3. Angew Chem Int Ed Engl. 2020. PMID: 32415712 Free PMC article.
Here, we report the development of TMX-2172, a heterobifunctional CDK2 degrader with degradation selectivity for CDK2 and CDK5 over not only CDK1, but transcriptional CDKs (CDK7 and CDK9) and cell cycle CDKs (CDK4 and CDK6) as well. ...
Here, we report the development of TMX-2172, a heterobifunctional CDK2 degrader with degradation selectivity for CDK2 and CDK5 over n …
CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity.
Sang Y, Li Y, Zhang Y, Alvarez AA, Yu B, Zhang W, Hu B, Cheng SY, Feng H. Sang Y, et al. Nat Commun. 2019 Sep 5;10(1):4013. doi: 10.1038/s41467-019-12001-2. Nat Commun. 2019. PMID: 31488827 Free PMC article.
However, the mechanism by which CDK5 promotes GBM tumorigenicity remains largely unknown. Here, we identify TRIM59 as a substrate of CDK5. ...Correlative expressions of the components of this pathway are clinically prognostic. Our findings suggest targeting CDK5 …
However, the mechanism by which CDK5 promotes GBM tumorigenicity remains largely unknown. Here, we identify TRIM59 as a substrate of …
324 results